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Amphetamine is known to inhibit monoamine oxidase, whereas the flexibility of amphetamine and its metabolites to inhibit many P450 isozymes and various enzymes hasn't been adequately elucidated. In vitro experiments with human microsomes reveal insignificant inhibition of CYP2D6 by amphetamine and insignificant inhibition of CYP1A2, 2D6, and 3A4 by